Monocyte-Derived Dendritic Cell Differentiation in Inflammatory Arthritis Is Regulated by the JAK/STAT Axis via NADPH Oxidase Regulation.

Marzaioli, Viviana; Canavan, Mary; Floudas, Achilleas; Wade, Siobhan C; Low, Candice; Veale, Douglas J; Fearon, Ursula

Marzaioli, Viviana; Canavan, Mary; Floudas, Achilleas; Wade, Siobhan C; Low, Candice; Veale, Douglas J; Fearon, Ursula.

Afiliação

Marzaioli V; Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Canavan M; Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Floudas A; Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Wade SC; Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Low C; Rheumatology EULAR Centre of Excellence, Centre for Arthritis & Rheumatic Diseases, St Vincent's University Hospital, University College Dublin, Dublin, Ireland.
Veale DJ; Rheumatology EULAR Centre of Excellence, Centre for Arthritis & Rheumatic Diseases, St Vincent's University Hospital, University College Dublin, Dublin, Ireland.
Fearon U; Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Front Immunol ; 11: 1406, 2020.

Article em En | MEDLINE | ID: mdl-32733468

Assuntos

Artrite Psoriásica/imunologia; Artrite Reumatoide/imunologia; Diferenciação Celular/imunologia; Células Dendríticas/imunologia; Transdução de Sinais/imunologia; Células Dendríticas/efeitos dos fármacos; Células Dendríticas/metabolismo; Humanos; Janus Quinases/metabolismo; Monócitos/imunologia; NADPH Oxidases/metabolismo; Piperidinas/farmacologia; Inibidores de Proteínas Quinases/farmacologia; Pirimidinas/farmacologia; Fatores de Transcrição STAT/metabolismo; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

NADPH oxidase; differentiation; inflammatory arthritis; monocyte-derived dendritic cells; tofacitinib

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Células Dendríticas / Transdução de Sinais / Artrite Psoriásica / Diferenciação Celular Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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