Quinovic acid purified from medicinal plant Fagonia indica mediates anticancer effects via death receptor 5.

Khayam, Asma Umer; Patel, Harsh; Faiola, Nicholas A; Figueroa Milla, Andre E; Dilshad, Erum; Mirza, Bushra; Huang, Ying; Sheikh, M Saeed

Khayam, Asma Umer; Patel, Harsh; Faiola, Nicholas A; Figueroa Milla, Andre E; Dilshad, Erum; Mirza, Bushra; Huang, Ying; Sheikh, M Saeed.

Afiliação

Khayam AU; Department of Pharmacology, State University of New York (SUNY), Upstate Medical University, 750 E Adams St, Syracuse, NY, 13210, USA.
Patel H; Department of Biochemistry, Faculty of Biological Sciences, Quaid-I-Azam University, Islamabad, Pakistan.
Faiola NA; Department of Pharmacology, State University of New York (SUNY), Upstate Medical University, 750 E Adams St, Syracuse, NY, 13210, USA.
Figueroa Milla AE; Department of Pharmacology, State University of New York (SUNY), Upstate Medical University, 750 E Adams St, Syracuse, NY, 13210, USA.
Dilshad E; Department of Pharmacology, State University of New York (SUNY), Upstate Medical University, 750 E Adams St, Syracuse, NY, 13210, USA.
Mirza B; Department of Bioinformatics and Biosciences, Faculty of Health and Life Sciences, Capital University of Science and Technology, Islamabad, Pakistan.
Huang Y; Department of Biochemistry, Faculty of Biological Sciences, Quaid-I-Azam University, Islamabad, Pakistan.
Sheikh MS; Department of Pharmacology, State University of New York (SUNY), Upstate Medical University, 750 E Adams St, Syracuse, NY, 13210, USA.

Mol Cell Biochem ; 474(1-2): 159-169, 2020 Nov.

Article em En | MEDLINE | ID: mdl-32734538

Assuntos

Antineoplásicos Fitogênicos/farmacologia; Neoplasias da Mama/tratamento farmacológico; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Neoplasias Pulmonares/tratamento farmacológico; Receptores do Ligante Indutor de Apoptose Relacionado a TNF/metabolismo; Triterpenos/farmacologia; Zygophyllaceae/química; Apoptose; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Proliferação de Células; Feminino; Humanos; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patologia; Extratos Vegetais/farmacologia; Plantas Medicinais/química; Receptores do Ligante Indutor de Apoptose Relacionado a TNF/genética; Células Tumorais Cultivadas

Palavras-chave

Apo2L/TRAIL; Breast cancer; DR5; Lung cancer; Natural product; Quinovic acid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triterpenos / Neoplasias da Mama / Regulação Neoplásica da Expressão Gênica / Zygophyllaceae / Receptores do Ligante Indutor de Apoptose Relacionado a TNF / Neoplasias Pulmonares / Antineoplásicos Fitogênicos Limite: Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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