Positive and Negative Regulation of DNA Replication Initiation.
Trends Genet
; 36(11): 868-879, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32739030
ABSTRACT
Genomic DNA is replicated every cell cycle by the programmed activation of replication origins at specific times and chromosomal locations. The factors that define the locations of replication origins and their typical activation times in eukaryotic cells are poorly understood. Previous studies highlighted the role of activating factors and epigenetic modifications in regulating replication initiation. Here, we review the role that repressive pathways - and their alleviation - play in establishing the genomic landscape of replication initiation. Several factors mediate this repression, in particular, factors associated with inactive chromatin. Repression can support organized, yet stochastic, replication initiation, and its absence could explain instances of rapid and random replication or re-replication.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Cromatina
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Origem de Replicação
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Epigênese Genética
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Replicação do DNA
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Complexo de Reconhecimento de Origem
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Células Eucarióticas
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article