Deep brain stimulation and cognition: Translational aspects.
Neurobiol Learn Mem
; 174: 107283, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32739395
ABSTRACT
Many neurological patients suffer from memory loss. To date, pharmacological treatments for memory disorders have limited and short-lasting effects. Therefore, researchers are investigating novel therapies such as deep brain stimulation (DBS) to alleviate memory impairments. Up to now stimulation of the fornix, nucleus basalis of Meynert and entorhinal cortex have been found to enhance memory performance. Here, we provide an overview of the different DBS targets and mechanisms within the memory circuit, which could be relevant for enhancing memory in patients. Future studies are warranted, accelerating the efforts to further unravel mechanisms of action of DBS in memory-related disorders and develop stimulation protocols based on these mechanisms.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Cognição
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Estimulação Encefálica Profunda
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Doença de Alzheimer
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Memória
Tipo de estudo:
Guideline
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article