Elevating sestrin2 attenuates endoplasmic reticulum stress and improves functional recovery through autophagy activation after spinal cord injury.

Li, Yao; Zhang, Jing; Zhou, Kailiang; Xie, Ling; Xiang, Guangheng; Fang, Mingqiao; Han, Wen; Wang, Xiangyang; Xiao, Jian

Li, Yao; Zhang, Jing; Zhou, Kailiang; Xie, Ling; Xiang, Guangheng; Fang, Mingqiao; Han, Wen; Wang, Xiangyang; Xiao, Jian.

Afiliação

Li Y; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Zhang J; Research Units of Clinical Translation of Cell Growth Factors and Diseases Research of Chinese Academy of Medical Science, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Zhou K; The Second School of Medicine, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Xie L; Research Units of Clinical Translation of Cell Growth Factors and Diseases Research of Chinese Academy of Medical Science, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Xiang G; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Fang M; Research Units of Clinical Translation of Cell Growth Factors and Diseases Research of Chinese Academy of Medical Science, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Han W; The Second School of Medicine, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Wang X; Research Units of Clinical Translation of Cell Growth Factors and Diseases Research of Chinese Academy of Medical Science, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Xiao J; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.

Cell Biol Toxicol ; 37(3): 401-419, 2021 06.

Article em En | MEDLINE | ID: mdl-32740777

Assuntos

Fator 4 Ativador da Transcrição/genética; Autofagia/genética; Peroxidases/genética; Traumatismos da Medula Espinal/genética; Quinases Proteína-Quinases Ativadas por AMP/genética; Animais; Apoptose/genética; Sobrevivência Celular/efeitos dos fármacos; Modelos Animais de Doenças; Estresse do Retículo Endoplasmático/genética; Regulação da Expressão Gênica/efeitos dos fármacos; Humanos; Camundongos; Neurônios/metabolismo; Neurônios/patologia; Transdução de Sinais/genética; Traumatismos da Medula Espinal/patologia; Traumatismos da Medula Espinal/terapia; Serina-Treonina Quinases TOR/genética; Tunicamicina/farmacologia

Palavras-chave

Apoptosis; Autophagy; Endoplasmic reticulum stress; Spinal cord injury; sestrin2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peroxidases / Traumatismos da Medula Espinal / Autofagia / Fator 4 Ativador da Transcrição Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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