Fermentable fibers upregulate suppressor of cytokine signaling1 in the colon of mice and intestinal Caco-2 cells through butyrate production.
Biosci Biotechnol Biochem
; 84(11): 2337-2346, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32741262
ABSTRACT
Short chain fatty acids (SCFAs), the microbial metabolites of fermentable dietary fibers exert multiple beneficial effects on mammals including humans. We examined the effects of fermentable dietary fibers on suppressor of cytokine signaling 1 (SOCS1), a negative regulator of inflammatory signaling, on the intestinal epithelial cells of the mouse colon and human intestinal Caco-2 cells, specifically focusing on the role of SCFAs. Feeding fermentable fibers, guar gum (GG) and partially hydrolyzed GG (PHGG) increased SOCS1 expression in the colon and the cecal pool of some SCFAs including acetate, propionate, and butyrate. The antibiotic administration abolished the GG-mediated SOCS1 expression in the colon. In Caco-2 cells, butyrate, but not other SCFAs, increased SOCS1 expression. Taken together, fermentable fibers such as GG and PHGG upregulate the colonic SOCS1 expression, possibly through the increased production of butyrate in mice and can be a potential tool in the fight against inflammatory diseases. Abbreviations GG Guar gum; GPR G protein-coupled receptor; IL Interleukin; JAK Janus kinase; NF- κB Nuclear factor-kappa B; PHGG Partially hydrolyzed guar gum; SCFA Short chain fatty acid; SOCS Suppressor of cytokine signaling; STAT Signal transducer and activator of transcription; TLR Toll-like receptor.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Butiratos
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Fibras na Dieta
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Regulação para Cima
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Colo
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Fermentação
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Proteína 1 Supressora da Sinalização de Citocina
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Intestinos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article