Risk Prediction Method for Anticholinergic Action Using Auto-quantitative Structure-Activity Relationship and Docking Study with Molecular Operating Environment.

Yuyama, Materu; Ito, Takeshi; Arai, Yumiko; Kadowaki, Yuki; Iiyama, Natsumi; Keino, Ayako; Hiraoka, Yurina; Kanaya, Takayuki; Momose, Yasuyuki; Kurihara, Masaaki

Yuyama, Materu; Ito, Takeshi; Arai, Yumiko; Kadowaki, Yuki; Iiyama, Natsumi; Keino, Ayako; Hiraoka, Yurina; Kanaya, Takayuki; Momose, Yasuyuki; Kurihara, Masaaki.

Afiliação

Yuyama M; Graduate School of Pharmaceutical Sciences, International University of Health and Welfare Graduate School.
Ito T; Graduate School of Pharmaceutical Sciences, International University of Health and Welfare Graduate School.
Arai Y; Department of Pharmaceutical Sciences, International University of Health and Welfare.
Kadowaki Y; Graduate School of Pharmaceutical Sciences, International University of Health and Welfare Graduate School.
Iiyama N; Department of Pharmaceutical Sciences, International University of Health and Welfare.
Keino A; Department of Pharmaceutical Sciences, International University of Health and Welfare.
Hiraoka Y; Department of Pharmaceutical Sciences, International University of Health and Welfare.
Kanaya T; Department of Pharmaceutical Sciences, International University of Health and Welfare.
Momose Y; Department of Pharmaceutical Sciences, International University of Health and Welfare.
Kurihara M; Graduate School of Pharmaceutical Sciences, International University of Health and Welfare Graduate School.

Chem Pharm Bull (Tokyo) ; 68(8): 773-778, 2020.

Article em En | MEDLINE | ID: mdl-32741919

Assuntos

Antagonistas Colinérgicos/química; Simulação de Acoplamento Molecular; Relação Quantitativa Estrutura-Atividade; Algoritmos; Sítios de Ligação; Antagonistas Colinérgicos/uso terapêutico; Humanos; Análise dos Mínimos Quadrados; Modelos Lineares; Sintomas do Trato Urinário Inferior/tratamento farmacológico; Sintomas do Trato Urinário Inferior/patologia; Receptor Muscarínico M3/química; Receptor Muscarínico M3/metabolismo

Palavras-chave

anticholinergic action; docking study; in silico; lower urinary tract symptom; quantitative structureactivity relationship

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antagonistas Colinérgicos / Relação Quantitativa Estrutura-Atividade / Simulação de Acoplamento Molecular Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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