Preliminary and Comparative Experiment Study Between 18F-Flurpiridaz and 13N-NH3·H2O Myocardial Perfusion Imaging With PET/CT in Miniature Pigs.
Mol Imaging
; 19: 1536012120947506, 2020.
Article
em En
| MEDLINE
| ID: mdl-32758064
ABSTRACT
OBJECTVES To comparatively explore the differences between 18F-Flurpiridaz and 13N-NH3·H2O PET/CT myocardial perfusion imaging in miniature pigs. METHODS:
Ten Bama minipigs were divided into normal group and myocardial infarction group. The changes of the ratio of left ventricular myocardium to main organs with time were calculated and the best imaging time was confirmed for 18F-Flurpiridaz imaging in normal group. The image quality score, summed rest score(SRS), Extend, total perfusion deficit(TPD) and left ventricle ejection fraction(LVEF) were respectively compared for 18F-Flurpiridaz and 13N-NH3·H2O in infarction group.RESULTS:
18F-Flurpiridaz was rapid distributed in myocardium, and the background counts of cardiac cavity were very low, and no obvious interference extracardiac radioactivity was observed. The radioactive ratio of the left ventricular myocardium to cardiac blood pool and adjacent liver were high. Compared with 13N-NH3·H2O, there were no significant differences in functional parameters, including SRS, Extend, TPD and LVEF.CONCLUSION:
The results preliminaryly show that 18F-FIurpiridaz is a promising positron MPI agent with good image quality, ability of accurately evaluating cardiac function, and also convenience for application.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Piridazinas
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Água
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Imagem de Perfusão do Miocárdio
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Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
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Amônia
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article