Ethanolic extract of Artemisia campestris subsp. glutinosa (Besser) Batt. inhibits HIV-1 replication in vitro through the activity of terpenes and flavonoids on viral entry and NF-&#954;B pathway.

Apaza Ticona, L; Bermejo, P; Guerra, J A; Abad, M J; Beltrán, M; Martín Lázaro, R; Alcamí, J; Bedoya, L M

Ethanolic extract of Artemisia campestris subsp. glutinosa (Besser) Batt. inhibits HIV-1 replication in vitro through the activity of terpenes and flavonoids on viral entry and NF-κB pathway.

Apaza Ticona, L; Bermejo, P; Guerra, J A; Abad, M J; Beltrán, M; Martín Lázaro, R; Alcamí, J; Bedoya, L M.

Afiliação

Apaza Ticona L; Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid, Plza. Ramón y Cajal S/n, 28040, Madrid, Spain; Department of Organic Chemistry, Faculty of Sciences, Universidad Autónoma de Madrid, Cantoblanco, 28049, Madrid, Spain. Electronic address: lu
Bermejo P; Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid, Plza. Ramón y Cajal S/n, 28040, Madrid, Spain. Electronic address: naber@ucm.es.
Guerra JA; Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid, Plza. Ramón y Cajal S/n, 28040, Madrid, Spain. Electronic address: jaguerra@ucm.es.
Abad MJ; Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid, Plza. Ramón y Cajal S/n, 28040, Madrid, Spain. Electronic address: mjabad6326@gmail.com.
Beltrán M; AIDS Immunopathology Department, National Centre of Microbiology, Instituto de Salud Carlos III, Ctra. Pozuelo Km. 2, 28224, Madrid, Spain. Electronic address: mbeltran@isciii.es.
Martín Lázaro R; Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid, Plza. Ramón y Cajal S/n, 28040, Madrid, Spain. Electronic address: rubema03@ucm.es.
Alcamí J; AIDS Immunopathology Department, National Centre of Microbiology, Instituto de Salud Carlos III, Ctra. Pozuelo Km. 2, 28224, Madrid, Spain. Electronic address: ppalcami@isciii.es.
Bedoya LM; Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid, Plza. Ramón y Cajal S/n, 28040, Madrid, Spain; AIDS Immunopathology Department, National Centre of Microbiology, Instituto de Salud Carlos III, Ctra. Pozuelo Km. 2, 28224, Madrid, Spain. Ele

J Ethnopharmacol ; 263: 113163, 2020 Dec 05.

Article em En | MEDLINE | ID: mdl-32758575

Assuntos

Artemisia; Flavonoides/farmacologia; HIV-1/efeitos dos fármacos; NF-kappa B/antagonistas & inibidores; Extratos Vegetais/farmacologia; Terpenos/farmacologia; Antivirais/química; Antivirais/isolamento & purificação; Antivirais/farmacologia; Relação Dose-Resposta a Droga; Etanol/química; Etanol/isolamento & purificação; Etanol/farmacologia; Flavonoides/química; Flavonoides/isolamento & purificação; Células HEK293; HIV-1/fisiologia; Humanos; NF-kappa B/metabolismo; Componentes Aéreos da Planta; Extratos Vegetais/química; Extratos Vegetais/isolamento & purificação; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/fisiologia; Terpenos/química; Terpenos/isolamento & purificação; Replicação Viral/efeitos dos fármacos; Replicação Viral/fisiologia

Palavras-chave

Antiretrovirals; Artemisia; Field wormwood; HIV; NFκB; Natural products

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terpenos / Flavonoides / Extratos Vegetais / NF-kappa B / HIV-1 / Artemisia Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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