Zinc(II), copper(II) and nickel(II) ions improve the selectivity of tetra-cationic platinum(II) porphyrins in photodynamic therapy and stimulate antioxidant defenses in the metastatic melanoma lineage (A375).

Klein Couto, Gabriela; Rodrigues, João Carlos; Pacheco, Bruna Silveira; Damé Simões, Lucas; Paschoal, Júlia Damé; Seixas, Fabiana Kommling; Acunha, Thiago V; Iglesias, Bernardo Almeida; Collares, Tiago

Klein Couto, Gabriela; Rodrigues, João Carlos; Pacheco, Bruna Silveira; Damé Simões, Lucas; Paschoal, Júlia Damé; Seixas, Fabiana Kommling; Acunha, Thiago V; Iglesias, Bernardo Almeida; Collares, Tiago.

Afiliação

Klein Couto G; Molecular and Cellular Oncology Research Group, Cancer Biotechnology Laboratory, Technological Development Center, Federal University of Pelotas, Pelotas, Brazil. Electronic address: gaby_kc@yahoo.com.br.
Rodrigues JC; Molecular and Cellular Oncology Research Group, Cancer Biotechnology Laboratory, Technological Development Center, Federal University of Pelotas, Pelotas, Brazil. Electronic address: jcrodriguesjr@hotmail.com.
Pacheco BS; Molecular and Cellular Oncology Research Group, Cancer Biotechnology Laboratory, Technological Development Center, Federal University of Pelotas, Pelotas, Brazil. Electronic address: pacheco.sbruna@gmail.com.
Damé Simões L; Molecular and Cellular Oncology Research Group, Cancer Biotechnology Laboratory, Technological Development Center, Federal University of Pelotas, Pelotas, Brazil. Electronic address: lucasdame@hotmail.com.
Paschoal JD; Molecular and Cellular Oncology Research Group, Cancer Biotechnology Laboratory, Technological Development Center, Federal University of Pelotas, Pelotas, Brazil. Electronic address: juliadfp@outlook.com.
Seixas FK; Molecular and Cellular Oncology Research Group, Cancer Biotechnology Laboratory, Technological Development Center, Federal University of Pelotas, Pelotas, Brazil. Electronic address: seixas.fk@gmail.com.
Acunha TV; Laboratory of Bioinorganic and Porphyrinoid Materials, Chemistry Department, Federal University of Santa Maria, Santa Maria, Brazil. Electronic address: thiagovacunha@hotmail.com.
Iglesias BA; Laboratory of Bioinorganic and Porphyrinoid Materials, Chemistry Department, Federal University of Santa Maria, Santa Maria, Brazil. Electronic address: bernardopgq@gmail.com.
Collares T; Molecular and Cellular Oncology Research Group, Cancer Biotechnology Laboratory, Technological Development Center, Federal University of Pelotas, Pelotas, Brazil. Electronic address: collares.t@gmail.com.

Photodiagnosis Photodyn Ther ; 31: 101942, 2020 Sep.

Article em En | MEDLINE | ID: mdl-32758669

Assuntos

Melanoma; Fotoquimioterapia; Porfirinas; Antioxidantes/farmacologia; Cobre; Humanos; Melanoma/tratamento farmacológico; Níquel; Fotoquimioterapia/métodos; Fármacos Fotossensibilizantes/farmacologia; Platina; Porfirinas/farmacologia; Zinco

Palavras-chave

Cancer; Endothelin receptor (ERT-B); LDL receptor; Metalloporphyrins; Photodynamic Therapy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Porfirinas / Melanoma Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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