CD4- and CD8-expressing cells in the chambers of normal, cataract and uveitic eyes: A comparative study in dogs.
Res Vet Sci
; 132: 393-399, 2020 Oct.
Article
em En
| MEDLINE
| ID: mdl-32758722
ABSTRACT
The main aims of this study were to determine whether CD4+ and CD8+ cells are present in the normal chambers of the eye in dogs and to verify the hypothesis that uncomplicated cataract may be associated with the local recruitment of CD4+ and CD8+ cells. The presence of CD4+ and CD8+ cells was detected in aqueous humor (AH) of normal and cataract eyes. The study did not reveal differences in the percentage and absolute number of CD4+ cells between normal and cataract eyes. However, the values of these parameters in AH from cataract eyes were approximately 2- and 3-fold higher than in normal eyes, respectively. The mean percentage and absolute count of CD8+ cells increased approximately by 2.7- and 6-fold, respectively, in AH samples from cataract eyes compared to normal ones. The absolute count of CD4+ and CD8+ cells in AH of uveitic eyes was approximately 5- and 3-fold higher than in cataract eyes. The results indicate that CD4+ and CD8+ cells occur constitutively in the normal chambers of the eye in dogs. However, it should be pointed out that both of these cell populations appeared in trace amounts. The development of uncomplicated cataract in dogs may not be immunologically neutral in terms of the local immune response, but it may be associated with the recruitment of CD8+ cells into the eye chambers. This event does not seem to be of an inflammatory nature because it appears on a scale a few times smaller than in the course of uveitis.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Uveíte
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Catarata
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Linfócitos T CD4-Positivos
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Linfócitos T CD8-Positivos
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Doenças do Cão
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Cães
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Olho
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article