Efficacy of a Novel Mitochondrial-Derived Peptide in a Porcine Model of Myocardial Ischemia/Reperfusion Injury.

Sharp, Thomas E; Gong, Zhenwei; Scarborough, Amy; Goetzman, Eric S; Ali, Murtuza J; Spaletra, Pablo; Lefer, David J; Muzumdar, Radhika H; Goodchild, Traci T

Sharp, Thomas E; Gong, Zhenwei; Scarborough, Amy; Goetzman, Eric S; Ali, Murtuza J; Spaletra, Pablo; Lefer, David J; Muzumdar, Radhika H; Goodchild, Traci T.

Afiliação

Sharp TE; Cardiovascular Center of Excellence, School of Medicine, Louisiana State University Health Science Center, New Orleans, Louisiana.
Gong Z; Department of Pediatrics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Scarborough A; Cardiovascular Center of Excellence, School of Medicine, Louisiana State University Health Science Center, New Orleans, Louisiana.
Goetzman ES; Department of Pediatrics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Ali MJ; Cardiovascular Center of Excellence, School of Medicine, Louisiana State University Health Science Center, New Orleans, Louisiana.
Spaletra P; Cardiovascular Center of Excellence, School of Medicine, Louisiana State University Health Science Center, New Orleans, Louisiana.
Lefer DJ; Cardiovascular Center of Excellence, School of Medicine, Louisiana State University Health Science Center, New Orleans, Louisiana.
Muzumdar RH; Department of Pharmacology and Experimental Therapeutics, School of Medicine, Louisiana State University Health Science Center, New Orleans, Louisiana.
Goodchild TT; Department of Pediatrics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

JACC Basic Transl Sci ; 5(7): 699-714, 2020 Jul.

Article em En | MEDLINE | ID: mdl-32760857

Palavras-chave

AAR, area-at-risk; Bax, Bcl-2associated X protein; DAPI, 4',6-diamidino-2-phenylindole; ELISA, enzyme-linked immunoadsorbent assay; HNG, S14G-humanin analogue; IGFBP3, insulin-like growth factorbinding protein-3; IV, intravenously; LAD, left anterior coronary artery; LV, left ventricular; MDP, mitochondrial-derived peptide; MI, myocardial infarction; MI/R, myocardial ischemia/reperfusion; NIZ, nonischemic zone; RMBF, regional myocardial blood flow; STAT, signal transducer and activator of transcription; TBARS, thiobarbituric acidreactive substances; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; acute myocardial infarction; adjunctive therapy; cTnI, cardiac troponin I; h-FABP, heart fatty acidbinding protein; large animal model; mitochondrial-derived peptide; myocardial ischemia-reperfusion injury

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article