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Polymethylated Phloroglucinol Meroterpenoids from Rhodomyrtus tomentosa and Their Antibacterial and Acetylcholinesterase Inhibitory Effects.
Liu, Hui; Li, Ping; Bi, Li-Sha; Wu, Wen-Juan; Yan, Huan; He, Li; Qin, Xu-Jie; Liu, Hai-Yang.
Afiliação
  • Liu H; State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
  • Li P; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
  • Bi LS; State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
  • Wu WJ; School of Chemical Science and Technology, Yunnan University, Kunming, 650224, P. R. China.
  • Yan H; State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
  • He L; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
  • Qin XJ; Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, P. R. China.
  • Liu HY; State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
Chem Biodivers ; 17(10): e2000489, 2020 Oct.
Article em En | MEDLINE | ID: mdl-32761773
ABSTRACT
Rhotomentodiones C-E, three new polymethylated phloroglucinol meroterpenoids with diverse configurations, were isolated from the twigs and leaves of Rhodomyrtus tomentosa. Their structures and absolute configurations were established mainly by means of comprehensive spectroscopic data and electron circular dichroism (ECD) calculation. Among them, Rhotomentodione D (2) exhibited both antibacterial activity with an MIC value of 12.5 µg/mL against Propionibacterium acnes and AChE inhibitory activity with an IC50 value of 22.9 µm.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Floroglucinol / Terpenos / Extratos Vegetais / Inibidores da Colinesterase / Myrtaceae / Antibacterianos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Floroglucinol / Terpenos / Extratos Vegetais / Inibidores da Colinesterase / Myrtaceae / Antibacterianos Idioma: En Ano de publicação: 2020 Tipo de documento: Article