Contribution of CYP24A1 variants in coronary heart disease among the Chinese population.
Lipids Health Dis
; 19(1): 181, 2020 Aug 06.
Article
em En
| MEDLINE
| ID: mdl-32762692
ABSTRACT
BACKGROUND:
Cytochrome P450 (CYPs) participate in the mechanisms of cardiovascular disease. The purpose of this research was to evaluate the contributions of CYP24A1 variants to coronary heart disease (CHD) among the Chinese Han population.METHODS:
This study included 505 CHD cases and 508 controls. Four variants of CYP24A1 (rs2762934, rs1570669, rs6068816 and rs2296241) were chosen and genotyped by the Agena MassARRAY system among the Chinese population. The linkage between CYP24A1 variants and CHD risk were assessed by logistic regression to compute the odds ratio (OR) and 95% confidence interval (CI). Then, multifactor dimensionality reduction (MDR) was applied to analyze the interactions of CYP24A1 variants.RESULTS:
The results of this study showed that CYP24A1 rs6068816 significantly enhanced CHD risk in multiple genetic models (allele P = 0.014; codominant P = 0.015; dominant P = 0.043; recessive P = 0.040; additive P = 0.013), whereas rs2296241 was likely to protect individuals from CHD (codominant P = 0.019; recessive P = 0.013; additive P = 0.033). Stratification analysis revealed that CYP24A1 polymorphisms had strong relationships with CHD risk that were dependent on age, sex, Gensini grade and smoking status (P < 0.05). Moreover, a four-locus model (rs2762934, rs1570669, rs6068816 and rs2296241) had significant impact on CHD risk in MDR analysis.CONCLUSION:
It revealed that CYP24A1 variants were significantly linked with CHD susceptibility in the Chinese population.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença das Coronárias
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Polimorfismo de Nucleotídeo Único
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Vitamina D3 24-Hidroxilase
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article