Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells.

Pavlovic, Marijana; Tadic, Ana; Gligorijevic, Nevenka; Poljarevic, Jelena; Petrovic, Tamara; Dojcinovic, Biljana; Savic, Aleksandar; Radulovic, Sinisa; Grguric-Sipka, Sanja; Arandelovic, Sandra

Pavlovic, Marijana; Tadic, Ana; Gligorijevic, Nevenka; Poljarevic, Jelena; Petrovic, Tamara; Dojcinovic, Biljana; Savic, Aleksandar; Radulovic, Sinisa; Grguric-Sipka, Sanja; Arandelovic, Sandra.

Afiliação

Pavlovic M; Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia.
Tadic A; Department of General and Inorganic Chemistry, University of Belgrade-Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.
Gligorijevic N; Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia.
Poljarevic J; Department of General and Inorganic Chemistry, University of Belgrade-Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia. Electronic address: jelenal@chem.bg.ac.rs.
Petrovic T; Department of General and Inorganic Chemistry, University of Belgrade-Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.
Dojcinovic B; Centre of Chemistry Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia.
Savic A; Department of General and Inorganic Chemistry, University of Belgrade-Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.
Radulovic S; Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia.
Grguric-Sipka S; Department of General and Inorganic Chemistry, University of Belgrade-Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia. Electronic address: sanjag@chem.bg.ac.rs.
Arandelovic S; Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia.

J Inorg Biochem ; 210: 111155, 2020 09.

Article em En | MEDLINE | ID: mdl-32768729

Assuntos

Antineoplásicos/farmacologia; Benzamidas/farmacologia; Complexos de Coordenação/farmacologia; Inibidores de Poli(ADP-Ribose) Polimerases/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/metabolismo; Proteína BRCA1/genética; Benzamidas/síntese química; Benzamidas/metabolismo; Neoplasias da Mama/tratamento farmacológico; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Complexos de Coordenação/síntese química; Complexos de Coordenação/metabolismo; DNA/metabolismo; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Ligantes; Mutação; Plasmídeos/metabolismo; Poli(ADP-Ribose) Polimerase-1/antagonistas & inibidores; Inibidores de Poli(ADP-Ribose) Polimerases/síntese química; Inibidores de Poli(ADP-Ribose) Polimerases/metabolismo; Rutênio/química

Palavras-chave

Antitumor agents; Breast cancer; PARP inhibitor; Ruthenium(II)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzamidas / Complexos de Coordenação / Inibidores de Poli(ADP-Ribose) Polimerases / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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