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Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer's disease.
He, Feng; Ran, Yingying; Li, Xiaoyang; Wang, Defeng; Zhang, Qiuqiong; Lv, Jiahui; Yu, Chenggong; Qu, Ying; Zhang, Xiangna; Xu, Ana; Wei, Chao; Chou, C James; Wu, Jingde.
Afiliação
  • He F; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Shandong University, 44 West Wenhua Road, 250012 Ji'nan, Shandong, PR China.
  • Ran Y; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Shandong University, 44 West Wenhua Road, 250012 Ji'nan, Shandong, PR China.
  • Li X; School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266071, PR China.
  • Wang D; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Shandong University, 44 West Wenhua Road, 250012 Ji'nan, Shandong, PR China.
  • Zhang Q; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Shandong University, 44 West Wenhua Road, 250012 Ji'nan, Shandong, PR China.
  • Lv J; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Shandong University, 44 West Wenhua Road, 250012 Ji'nan, Shandong, PR China.
  • Yu C; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Shandong University, 44 West Wenhua Road, 250012 Ji'nan, Shandong, PR China.
  • Qu Y; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Shandong University, 44 West Wenhua Road, 250012 Ji'nan, Shandong, PR China.
  • Zhang X; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Shandong University, 44 West Wenhua Road, 250012 Ji'nan, Shandong, PR China.
  • Xu A; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Shandong University, 44 West Wenhua Road, 250012 Ji'nan, Shandong, PR China.
  • Wei C; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Shandong University, 44 West Wenhua Road, 250012 Ji'nan, Shandong, PR China.
  • Chou CJ; Department of Drug Discovery and Biomedical Science, College of Pharmacy, Medical University of South Carolina, Charleston, SC 29425, United States.
  • Wu J; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science, Shandong University, 44 West Wenhua Road, 250012 Ji'nan, Shandong, PR China. Electronic address: wujingde70@sdu.edu.cn.
Bioorg Chem ; 103: 104109, 2020 10.
Article em En | MEDLINE | ID: mdl-32768741
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Receptores de N-Metil-D-Aspartato / Fármacos Neuroprotetores / Inibidores de Histona Desacetilases / Doença de Alzheimer / Histona Desacetilases Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Receptores de N-Metil-D-Aspartato / Fármacos Neuroprotetores / Inibidores de Histona Desacetilases / Doença de Alzheimer / Histona Desacetilases Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article