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Differences in Capacity of High-Density Lipoprotein Cholesterol Efflux Between Patients With Systemic Lupus Erythematosus and Rheumatoid Arthritis.
Quevedo-Abeledo, Juan C; Sánchez-Pérez, Hiurma; Tejera-Segura, Beatriz; de Armas-Rillo, Laura; Armas-González, Estefanía; Machado, José David; González-Gay, Miguel A; Díaz-González, Federico; Ferraz-Amaro, Iván.
Afiliação
  • Quevedo-Abeledo JC; Hospital Doctor Negrín, Gran Canaria, Spain.
  • Sánchez-Pérez H; Hospital Universitario de Canarias, Tenerife, Spain.
  • Tejera-Segura B; Hospital Insular de Gran Canaria, Gran Canaria, Spain.
  • de Armas-Rillo L; Universidad Europea de Canarias, Tenerife, Spain.
  • Armas-González E; Universidad de La Laguna, Tenerife, Spain.
  • Machado JD; Universidad de La Laguna, Tenerife, Spain.
  • González-Gay MA; Hospital Universitario Marqués de Valdecilla, Santander, Spain.
  • Díaz-González F; Hospital Universitario de Canarias, Tenerife, and Universidad de La Laguna, La Laguna, Spain.
  • Ferraz-Amaro I; Hospital Universitario de Canarias, Tenerife, Spain.
Arthritis Care Res (Hoboken) ; 73(11): 1590-1596, 2021 11.
Article em En | MEDLINE | ID: mdl-32770725
OBJECTIVE: Cholesterol efflux capacity (CEC) is the ability of high-density lipoprotein (HDL) cholesterol to accept cholesterol from macrophages. Lipid profiles and CEC appear to be altered in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) due to disease activity and inflammation. CEC has been linked to cardiovascular events in the general population and to subclinical atherosclerosis in SLE and RA patients. The aim of this study was to establish whether CEC varies between patients with SLE and those with RA. METHODS: The study encompassed 460 individuals (195 SLE patients and 265 patients with RA). CEC (using an in vitro assay) and concentrations of lipoprotein serum were assessed in both populations. A multivariable regression analysis was performed to study whether CEC differs between SLE patients and RA patients. RESULTS: Comparison of lipid patterns revealed that patients with RA have lower HDL cholesterol and higher apolipoprotein B serum levels than SLE patients. CEC was downregulated in SLE patients compared to patients with RA (ß -12 [95% confidence interval -13, -10], P < 0.001). It occurred independently of traditional cardiovascular risk factors, statin use, disease-related data, and other variations in the lipid profile related to the diseases. CONCLUSION: Patients with RA have a more proatherogenic lipid pattern compared to those with SLE. However, CEC seems to be more damaged in SLE patients than in RA patients.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / HDL-Colesterol / Lúpus Eritematoso Sistêmico Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / HDL-Colesterol / Lúpus Eritematoso Sistêmico Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2021 Tipo de documento: Article