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Baseline Results of the West London lung cancer screening pilot study - Impact of mobile scanners and dual risk model utilisation.
Bartlett, Emily C; Kemp, Samuel V; Ridge, Carole A; Desai, Sujal R; Mirsadraee, Saeed; Morjaria, Jaymin B; Shah, Pallav L; Popat, Sanjay; Nicholson, Andrew G; Rice, Alexandra J; Jordan, Simon; Begum, Sofina; Mani, Aleksander; Derbyshire, Jane; Morris, Katie; Chen, Michelle; Peacock, Christine; Addis, James; Martins, Maria; Kaye, Stan B; Padley, Simon P G; Devaraj, Anand.
Afiliação
  • Bartlett EC; Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK.
  • Kemp SV; Royal Brompton and Harefield NHS Foundation Trust, Department of Respiratory Medicine, Sydney Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK.
  • Ridge CA; Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK.
  • Desai SR; Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK.
  • Mirsadraee S; Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK.
  • Morjaria JB; Royal Brompton and Harefield NHS Foundation Trust, Department of Respiratory Medicine, Harefield Hospital, Hill End Road, Harefield, UB9 6JH, UK.
  • Shah PL; Royal Brompton and Harefield NHS Foundation Trust, Department of Respiratory Medicine, Sydney Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK.
  • Popat S; National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK; Lung Unit, Royal Marsden Hospital, Fulham Road, London, SW6 3JJ, UK; Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK.
  • Nicholson AG; National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK; Royal Brompton and Harefield NHS Foundation Trust, Department of Histopathology, Sydney Street, London, SW3 6NP, UK.
  • Rice AJ; Royal Brompton and Harefield NHS Foundation Trust, Department of Histopathology, Sydney Street, London, SW3 6NP, UK.
  • Jordan S; Royal Brompton and Harefield NHS Foundation Trust, Department of Thoracic Surgery, Sydney Street, London, SW3 6NP, UK.
  • Begum S; Royal Brompton and Harefield NHS Foundation Trust, Department of Thoracic Surgery, Sydney Street, London, SW3 6NP, UK.
  • Mani A; Royal Brompton and Harefield NHS Foundation Trust, Department of Thoracic Surgery, Sydney Street, London, SW3 6NP, UK.
  • Derbyshire J; RM Partners, The West London Cancer Alliance, 5th Floor, Alliance House, 12 Caxton Street, London, SW1H 0QS, UK.
  • Morris K; RM Partners, The West London Cancer Alliance, 5th Floor, Alliance House, 12 Caxton Street, London, SW1H 0QS, UK.
  • Chen M; RM Partners, The West London Cancer Alliance, 5th Floor, Alliance House, 12 Caxton Street, London, SW1H 0QS, UK.
  • Peacock C; Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK.
  • Addis J; Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK.
  • Martins M; Respiratory Biomedical Research Unit, Royal Brompton Hospital and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK.
  • Kaye SB; RM Partners, Sycamore House, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, SM2 5PT, UK.
  • Padley SPG; Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK.
  • Devaraj A; Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK. Electronic address: A.Devaraj@rbht.nhs.uk.
Lung Cancer ; 148: 12-19, 2020 10.
Article em En | MEDLINE | ID: mdl-32771715
OBJECTIVES: The West London lung screening pilot aimed to identify early-stage lung cancer by targeting low-dose CT (LDCT) to high risk participants. Successful implementation of screening requires maximising participant uptake and identifying those at highest risk. As well as reporting pre-specified baseline screening metrics, additional objectives were to 1) compare participant uptake between a mobile and hospital-based CT scanner and 2) evaluate the impact on cancer detection using two lung cancer risk models. METHODS: From primary care records, ever-smokers aged 60-75 were invited to a lung health check at a hospital or mobile site. Participants with PLCOM2012 6-yr risk ≥1.51 % and/or LLPv2 5-yr risk ≥2.0 % were offered a LDCT. Lung cancer detection rate, stage, and recall rates are reported. Participant uptake was compared at both sites (chi-squared test). LDCT eligibility and cancer detection rate were compared between those recruited under each risk model. RESULTS: Of 8366 potential participants invited, 1047/5135 (20.4 %) invitees responded to an invitation to the hospital site, and 702/3231 (21.7 %) to the mobile site (p = 0.14). The median distance travelled to the hospital site was less than to the mobile site (3.3 km vs 6.4 km, p < 0.01). Of 1159 participants eligible for a scan, 451/1159 (38.9 %) had a LLPv2 ≥2.0 % only, 71/1159 (6.1 %) had a PLCOM2012 ≥1.5 % only; 637/1159 (55.0 %) met both risk thresholds. Recall rate was 15.9 %. Lung cancer was detected in 29/1145 (2.5 %) participants scanned (stage 1, 58.6 %); 5/29 participants with lung cancer did not meet a PLCOM2012 threshold of ≥1.51 %; all had a LLPv2 ≥2.0 %. CONCLUSION: Targeted screening is effective in detecting early-stage lung cancer. Similar levels of participant uptake at a mobile and fixed site scanner were demonstrated, indicating that uptake was driven by factors in addition to scanner location. The LLPv2 model was more permissive; recruitment with PLCOM2012 alone would have missed several cancers.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Detecção Precoce de Câncer / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Humans País como assunto: Europa Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Detecção Precoce de Câncer / Neoplasias Pulmonares Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Humans País como assunto: Europa Idioma: En Ano de publicação: 2020 Tipo de documento: Article