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Discovery of novel integrase-LEDGF/p75 allosteric inhibitors based on a benzene scaffold.
Sugiyama, Shuichi; Iwaki, Tsutomu; Tamura, Yoshinori; Tomita, Kenji; Matsuoka, Eriko; Arita, Shuhei; Seki, Takahiro; Yoshinaga, Tomokazu; Kawasuji, Takashi.
Afiliação
  • Sugiyama S; Shionogi Pharmaceutical Research Center, Shionogi & Company, Limited, 1-1, Futabacho, 3-chome, Toyonaka, Osaka 561-0825, Japan. Electronic address: shuichi.sugiyama@shionogi.co.jp.
  • Iwaki T; Shionogi Pharmaceutical Research Center, Shionogi & Company, Limited, 1-1, Futabacho, 3-chome, Toyonaka, Osaka 561-0825, Japan.
  • Tamura Y; Shionogi Pharmaceutical Research Center, Shionogi & Company, Limited, 1-1, Futabacho, 3-chome, Toyonaka, Osaka 561-0825, Japan.
  • Tomita K; Shionogi Pharmaceutical Research Center, Shionogi & Company, Limited, 1-1, Futabacho, 3-chome, Toyonaka, Osaka 561-0825, Japan.
  • Matsuoka E; Shionogi Pharmaceutical Research Center, Shionogi & Company, Limited, 1-1, Futabacho, 3-chome, Toyonaka, Osaka 561-0825, Japan.
  • Arita S; Shionogi Pharmaceutical Research Center, Shionogi & Company, Limited, 1-1, Futabacho, 3-chome, Toyonaka, Osaka 561-0825, Japan.
  • Seki T; Shionogi Pharmaceutical Research Center, Shionogi & Company, Limited, 1-1, Futabacho, 3-chome, Toyonaka, Osaka 561-0825, Japan.
  • Yoshinaga T; Shionogi Pharmaceutical Research Center, Shionogi & Company, Limited, 1-1, Futabacho, 3-chome, Toyonaka, Osaka 561-0825, Japan.
  • Kawasuji T; Shionogi Pharmaceutical Research Center, Shionogi & Company, Limited, 1-1, Futabacho, 3-chome, Toyonaka, Osaka 561-0825, Japan.
Bioorg Med Chem ; 28(17): 115643, 2020 09 01.
Article em En | MEDLINE | ID: mdl-32773094
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Derivados de Benzeno / Peptídeos e Proteínas de Sinalização Intercelular / Regulação Alostérica Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Derivados de Benzeno / Peptídeos e Proteínas de Sinalização Intercelular / Regulação Alostérica Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article