Vulvar Hailey-Hailey disease treated with low-dose naltrexone: case report and literature review.
Arch Gynecol Obstet
; 302(5): 1081-1086, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32776297
ABSTRACT
PURPOSE:
To report a case of vulvar familial benign pemphigus, or Hailey-Hailey disease, treated successfully with low-dose naltrexone and to review the current literature.METHODS:
We report a case of a 71-year-old white woman with vulvar Hailey-Hailey disease recalcitrant to topical corticosteroids. After treatment with low-dose naltrexone, 3 mg nightly was initiated, the lesions began to heal and 5 months later her skin showed no lesions. A literature review on the use of low-dose naltrexone for Hailey-Hailey disease was performed. We searched the PubMed/MEDLINE databases for previous case reports using the key words ''Pemphigus, Benign Familial'' and ''naltrexone".RESULTS:
We found 35 more cases of Hailey-Hailey disease treated with naltrexone, showing promising results, reported until January 2020, with no major adverse effects.CONCLUSION:
Low-dose naltrexone may represent a cost-effective and successful treatment modality in nongeneralized Hailey-Hailey disease without serious adverse effects. Future prospective studies are needed to investigate this interesting therapeutic option.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Naltrexona
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Antagonistas de Entorpecentes
Tipo de estudo:
Observational_studies
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Systematic_reviews
Limite:
Aged
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Female
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article