IRE1&#945;/NOX4 signaling pathway mediates ROS-dependent activation of hepatic stellate cells in NaAsO<sub>2</sub> -induced liver fibrosis.

Tao, Ye; Qiu, Tianming; Yao, Xiaofeng; Jiang, Liping; Wang, Ningning; Jiang, Jintong; Jia, Xue; Wei, Sen; Zhang, Jingyuan; Zhu, Yuhan; Tian, Wenyue; Yang, Guang; Liu, Xiaofang; Liu, Shuang; Ding, Yang; Sun, Xiance

IRE1α/NOX4 signaling pathway mediates ROS-dependent activation of hepatic stellate cells in NaAsO₂ -induced liver fibrosis.

Tao, Ye; Qiu, Tianming; Yao, Xiaofeng; Jiang, Liping; Wang, Ningning; Jiang, Jintong; Jia, Xue; Wei, Sen; Zhang, Jingyuan; Zhu, Yuhan; Tian, Wenyue; Yang, Guang; Liu, Xiaofang; Liu, Shuang; Ding, Yang; Sun, Xiance.

Afiliação

Tao Y; Department of Occupational and Environmental Health, Dalian Medical University, Dalian, China.
Qiu T; Department of Occupational and Environmental Health, Dalian Medical University, Dalian, China.
Yao X; Department of Occupational and Environmental Health, Dalian Medical University, Dalian, China.
Jiang L; Experimental Teaching Center of Public Health, Dalian Medical University, Dalian, China.
Wang N; Department of Nutrition and Food Hygiene, Dalian Medical University, Dalian, China.
Jiang J; School of Foreign Languages, China Pharmaceutical University, Nanjing, Jiangsu, China.
Jia X; Department of Occupational and Environmental Health, Dalian Medical University, Dalian, China.
Wei S; Department of Occupational and Environmental Health, Dalian Medical University, Dalian, China.
Zhang J; Department of Occupational and Environmental Health, Dalian Medical University, Dalian, China.
Zhu Y; Department of Occupational and Environmental Health, Dalian Medical University, Dalian, China.
Tian W; Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, China.
Yang G; Department of Nutrition and Food Hygiene, Dalian Medical University, Dalian, China.
Liu X; Department of Nutrition and Food Hygiene, Dalian Medical University, Dalian, China.
Liu S; Department of Occupational and Environmental Health, Dalian Medical University, Dalian, China.
Ding Y; Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, China.
Sun X; Department of Occupational and Environmental Health, Dalian Medical University, Dalian, China.

J Cell Physiol ; 236(2): 1469-1480, 2021 02.

Article em En | MEDLINE | ID: mdl-32776539

Assuntos

Estresse do Retículo Endoplasmático/genética; Endorribonucleases/genética; Cirrose Hepática/genética; Complexos Multienzimáticos/genética; NADPH Oxidase 4/genética; Proteínas Serina-Treonina Quinases/genética; Animais; Arsenitos/toxicidade; Modelos Animais de Doenças; Regulação da Expressão Gênica/genética; Células Estreladas do Fígado/metabolismo; Células Estreladas do Fígado/patologia; Humanos; Cirrose Hepática/induzido quimicamente; Cirrose Hepática/patologia; Ratos; Ratos Sprague-Dawley; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais/genética; Compostos de Sódio/toxicidade

Palavras-chave

NOX4; ROS; arsenic; hepatic stellate cells; liver fibrosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Endorribonucleases / Estresse do Retículo Endoplasmático / NADPH Oxidase 4 / Cirrose Hepática / Complexos Multienzimáticos Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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