Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aß42 aggregation.

Flagmeier, Patrick; De, Suman; Michaels, Thomas C T; Yang, Xiaoting; Dear, Alexander J; Emanuelsson, Cecilia; Vendruscolo, Michele; Linse, Sara; Klenerman, David; Knowles, Tuomas P J; Dobson, Christopher M

Flagmeier, Patrick; De, Suman; Michaels, Thomas C T; Yang, Xiaoting; Dear, Alexander J; Emanuelsson, Cecilia; Vendruscolo, Michele; Linse, Sara; Klenerman, David; Knowles, Tuomas P J; Dobson, Christopher M.

Afiliação

Flagmeier P; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK.
De S; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK.
Michaels TCT; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK.
Yang X; Paulson School of Engineering and Applied Science, Harvard University, Cambridge, MA, USA.
Dear AJ; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK.
Emanuelsson C; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK.
Vendruscolo M; Paulson School of Engineering and Applied Science, Harvard University, Cambridge, MA, USA.
Linse S; Department of Chemistry, Division for Biochemistry and Structural Biology, Lund University, Lund, Sweden.
Klenerman D; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK.
Knowles TPJ; Department of Chemistry, Division for Biochemistry and Structural Biology, Lund University, Lund, Sweden.
Dobson CM; Department of Chemistry, University of Cambridge, Cambridge, UK. dk10012@cam.ac.uk.

Nat Struct Mol Biol ; 27(10): 886-891, 2020 10.

Article em En | MEDLINE | ID: mdl-32778821

Assuntos

Peptídeos beta-Amiloides/metabolismo; Fragmentos de Peptídeos/metabolismo; Agregação Patológica de Proteínas/metabolismo; Peptídeos beta-Amiloides/genética; Peptídeos beta-Amiloides/toxicidade; Cálcio/metabolismo; Permeabilidade da Membrana Celular; Proteínas de Choque Térmico HSP40/genética; Proteínas de Choque Térmico HSP40/metabolismo; Humanos; Cinética; Bicamadas Lipídicas; Microscopia de Fluorescência; Chaperonas Moleculares/genética; Chaperonas Moleculares/metabolismo; Imagem Molecular; Proteínas do Tecido Nervoso/genética; Proteínas do Tecido Nervoso/metabolismo; Fragmentos de Peptídeos/genética; Fragmentos de Peptídeos/toxicidade

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Peptídeos beta-Amiloides / Agregação Patológica de Proteínas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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