Human papillomavirus vaccine effectiveness within a cervical cancer screening programme: cohort study.
BJOG
; 128(3): 532-539, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-32779381
ABSTRACT
OBJECTIVE:
To assess the effectiveness of an HPV vaccination programme in reducing the risk of cervical abnormalities identified at subsequent screening.DESIGN:
Retrospective cohort study using administrative health data.SETTING:
General population of Ferrara Province, Italy. POPULATION Female residents born in 1986-1993 and participating in the organized cervical screening programme in 2011-2018, who were eligible for HPV vaccination in catch-up cohorts.METHODS:
Logistic regression to evaluate the potential association between abnormal cervical cytology and one, two, three or at least one dose of HPV vaccine. MAIN OUTCOMEMEASURES:
Cervical abnormalities, as predicted by low-grade or high-grade cytology, by number of vaccine doses, stratified by age.RESULTS:
The sample consisted of 7785 women (mean age 27.5 years, SD 2.3). Overall, 391 (5.0%) were vaccinated with ≥1 dose and 893 (11.5%) had abnormal cytology. Women receiving at least one vaccine dose were significantly less likely to have an abnormal cytology (adjusted odds ratio 0.52; 95% confidence interval 0.34-0.79). Similar results were observed for women receiving a single dose, for both bivalent and quadrivalent vaccines, and applying buffer periods (excluding cytological outcomes within 1 month, 6 months and 1 year of the first dose).CONCLUSIONS:
In the context of an organised cervical screening programme in Italy, catch-up HPV vaccination almost halved the risk of cytological abnormalities. TWEETABLE ABSTRACT Among Ferrara women, vaccination against human papillomavirus halved the risk of screening cervical abnormalities.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Colo do Útero
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Programas de Imunização
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Infecções por Papillomavirus
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Vacinas contra Papillomavirus
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Detecção Precoce de Câncer
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Evaluation_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Adult
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Female
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Humans
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article