Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Antibody Titers in Convalescent Plasma and Recipients in New Mexico: An Open Treatment Study in Patients With Coronavirus Disease 2019.
J Infect Dis
; 222(10): 1620-1628, 2020 10 13.
Article
em En
| MEDLINE
| ID: mdl-32779705
ABSTRACT
BACKGROUND:
Convalescent plasma (CP) is a potentially important therapy for coronavirus disease 2019 (COVID-19). However, knowledge regarding neutralizing antibody (NAb) titers in donor plasma and their impact in patients with acute COVID-19 remains largely undetermined. We measured NAb titers in CP and in patients with acute COVID-19 before and after transfusion through the traditional Food and Drug Administration investigational new drug pathway.METHODS:
We performed a single-arm interventional trial measuring NAb and total antibody titers before and after CP transfusion over a 14-day period in hospitalized patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection.RESULTS:
NAb titers in the donor CP units were low (<140 to 1160) and had no effect on recipient neutralizing activity 1 day after transfusion. NAb titers were detected in 6 of 12 patients on enrollment and in 11 of 12 at ≥2 time points. Average titers peaked on day 7 and declined toward day 14 (Pâ =â .004). Nab titers and immunoglobulin G levels were correlated in donor plasma units (ρâ =â 0.938; Pâ <â .001) and in the cumulative patient measures (ρâ =â 0.781; Pâ <â .001).CONCLUSIONS:
CP infusion did not alter recipient NAb titers. Prescreening of CP may be necessary for selecting donors with high titers of neutralizing activity for infusion into patients with COVID-19. CLINICAL TRIALS REGISTRATION NCT04434131.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
/
Doadores de Sangue
/
Infecções por Coronavirus
/
Anticorpos Neutralizantes
/
Betacoronavirus
/
Anticorpos Antivirais
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País como assunto:
America do norte
/
Mexico
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article