Divergent synthesis of 1,3,5-tri and 1,3-disubstituted pyrazoles under transition metal-free conditions.
Org Biomol Chem
; 18(33): 6487-6491, 2020 08 26.
Article
em En
| MEDLINE
| ID: mdl-32785327
ABSTRACT
Pyrazole cores are common structural motifs existing in various agrochemicals and pharmaceuticals. Herein, a transition metal-free, three-component reaction of arylaldehydes, ethyl acrylate and N-tosylhydrazones is described, which leads to the formation of 1,3,5-trisubstituted and 1,3-disubstituted pyrazoles divergently under slightly different conditions.
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MEDLINE
Idioma:
En
Ano de publicação:
2020
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Article