Conjugation Site Influences Antibody-Conjugated Drug PK Assays: Case Studies for Disulfide-Linked, Self-Immolating Next-Generation Antibody Drug Conjugates.

Lee, M Violet; Kaur, Surinder; Saad, Ola M

Lee, M Violet; Kaur, Surinder; Saad, Ola M.

Afiliação

Lee MV; Department of Bioanalytical Sciences, Assay Development and Technology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Kaur S; Department of Bioanalytical Sciences, Assay Development and Technology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Saad OM; Department of Bioanalytical Sciences, Assay Development and Technology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

Anal Chem ; 92(18): 12168-12175, 2020 09 15.

Article em En | MEDLINE | ID: mdl-32786429

Assuntos

Anticorpos Monoclonais/farmacocinética; Dissulfetos/farmacocinética; Imunoconjugados/farmacocinética; Anticorpos Monoclonais/análise; Cromatografia Líquida; Dissulfetos/análise; Humanos; Imunoensaio; Imunoconjugados/análise; Estrutura Molecular; Espectrometria de Massas em Tandem

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoconjugados / Dissulfetos / Anticorpos Monoclonais Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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