Prenylated Flavonoids from the Roots of Tephrosia rhodesica.
J Nat Prod
; 83(8): 2390-2398, 2020 08 28.
Article
em En
| MEDLINE
| ID: mdl-32790306
ABSTRACT
Five new compounds-rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)-along with 16 known secondary metabolites, were isolated from the CH2Cl2-CH3OH (11) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2-5, 9, 15, and 21 showed activity (100% at 10 µg and IC50 = 5-15 µM) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Raízes de Plantas
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Tephrosia
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article