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Somatic structural variation targets neurodevelopmental genes and identifies SHANK2 as a tumor suppressor in neuroblastoma.
Lopez, Gonzalo; Conkrite, Karina L; Doepner, Miriam; Rathi, Komal S; Modi, Apexa; Vaksman, Zalman; Farra, Lance M; Hyson, Eric; Noureddine, Moataz; Wei, Jun S; Smith, Malcolm A; Asgharzadeh, Shahab; Seeger, Robert C; Khan, Javed; Auvil, Jaime Guidry; Gerhard, Daniela S; Maris, John M; Diskin, Sharon J.
Afiliação
  • Lopez G; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Conkrite KL; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Doepner M; Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Rathi KS; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Modi A; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Vaksman Z; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Farra LM; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Hyson E; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Noureddine M; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Wei JS; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Smith MA; Genomics and Computational Biology, Biomedical Graduate Studies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
  • Asgharzadeh S; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Seeger RC; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Khan J; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Auvil JG; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Gerhard DS; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Maris JM; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
  • Diskin SJ; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Genome Res ; 30(9): 1228-1242, 2020 09.
Article em En | MEDLINE | ID: mdl-32796005
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genes Supressores de Tumor / Neurogênese / Variação Estrutural do Genoma / Proteínas do Tecido Nervoso / Neuroblastoma Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genes Supressores de Tumor / Neurogênese / Variação Estrutural do Genoma / Proteínas do Tecido Nervoso / Neuroblastoma Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article