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Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study.
Maggi, Pietro; Sati, Pascal; Nair, Govind; Cortese, Irene C M; Jacobson, Steven; Smith, Bryan R; Nath, Avindra; Ohayon, Joan; van Pesch, Vincent; Perrotta, Gaetano; Pot, Caroline; Théaudin, Marie; Martinelli, Vittorio; Scotti, Roberta; Wu, Tianxia; Du Pasquier, Renaud; Calabresi, Peter A; Filippi, Massimo; Reich, Daniel S; Absinta, Martina.
Afiliação
  • Maggi P; Department of Neurology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
  • Sati P; Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
  • Nair G; Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Cortese ICM; Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD.
  • Jacobson S; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.
  • Smith BR; Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD.
  • Nath A; Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD.
  • Ohayon J; Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD.
  • van Pesch V; Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD.
  • Perrotta G; Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD.
  • Pot C; Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD.
  • Théaudin M; Department of Neurology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
  • Martinelli V; Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
  • Scotti R; Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Wu T; Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Du Pasquier R; Departments of Neurology and Neurophysiology and Neuroimaging Research Unit, Ospedale San Raffaele and Università Vita e Salute, Milan, Italy.
  • Calabresi PA; Department of Neuroradiology, Ospedale San Raffaele and Università Vita e Salute, Milan, Italy.
  • Filippi M; Clinical Trials Unit, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD.
  • Reich DS; Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Absinta M; Department of Neurology, Johns Hopkins University, Baltimore, MD.
Ann Neurol ; 88(5): 1034-1042, 2020 11.
Article em En | MEDLINE | ID: mdl-32799417
ABSTRACT
In multiple sclerosis (MS), a subset of chronic active white matter lesions are identifiable on magnetic resonance imaging by their paramagnetic rims, and increasing evidence supports their association with severity of clinical disease. We studied their potential role in differential diagnosis, screening an international multicenter clinical research-based sample of 438 individuals affected by different neurological conditions (MS, other inflammatory, infectious, and non-inflammatory conditions). Paramagnetic rim lesions, rare in other neurological conditions (52% of MS vs 7% of non-MS cases), yielded high specificity (93%) in differentiating MS from non-MS. Future prospective multicenter studies should validate their role as a diagnostic biomarker. ANN NEUROL 2020;881034-1042.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esclerose Múltipla Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esclerose Múltipla Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article