Association Between Lipid Accumulation Product and Mild Cognitive Impairment in Patients with Type 2 Diabetes.
J Alzheimers Dis
; 77(1): 367-374, 2020.
Article
em En
| MEDLINE
| ID: mdl-32804130
ABSTRACT
BACKGROUND:
Diabetes may increase the risk of conversion of mild cognitive impairment (MCI) to dementia. Lipid accumulation product (LAP), an index of visceral obesity, has been shown to be a powerful predictor of insulin resistance and type 2 diabetes (T2D). However, little attention has been paid to the relationship between LAP and MCI in T2D.OBJECTIVE:
We aimed to investigate the association between the LAP index and MCI in patients with T2D.METHODS:
In total, 220 hospitalized patients with T2D, including 113 MCI patients and 107 patients with normal cognition, were enrolled in this cross-sectional study. We collected demographic, anthropometric, and biochemical data on each subject. The LAP index was calculated according to the following formulas [waist circumference (WC) (cm) - 65]×triglyceride (TG) (mmol/L) for males and [WC (cm) - 58] ×TG (mmol/L) for females.RESULTS:
Compared with patients with normal cognition, MCI patients were older and had a higher LAP index, WC, body mass index, and glycosylated hemoglobin A1c level, as well as a lower Montreal Cognitive Assessment score and education level (pâ<â0.05). After adjusting for confounding factors, LAP index was associated with MCI (ORâ=â1.047, 95% CIâ=â1.031-1.063, pâ<â0.01). The area under the ROC curve (AUC) for the LAP index was higher than that for WC and BMI.CONCLUSION:
A high LAP index is associated with an increased risk of MCI in T2D patients. The LAP index appears to be a good indicator of risk of MCI in patients with T2D.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 2
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Disfunção Cognitiva
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Produto da Acumulação Lipídica
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article