Synthesis of Aza-Eight-Membered Ring-Fused Indolines Initiated by Zn-Catalyzed C2 Alkylation of Indoles and Subsequent Base-Promoted Ring Expansion.
Org Lett
; 22(16): 6532-6536, 2020 08 21.
Article
em En
| MEDLINE
| ID: mdl-32806175
ABSTRACT
A novel and efficient synthesis of aza-eight-membered ring-fused indolines has been developed. This process is realized by zinc-catalyzed C2 alkylation of indoles and subsequent base-promoted ring expansion of the newly formed six-membered ring with alkynes. Easily accessible starting materials, good functional group tolerance, and high atom economy make this procedure attractive.
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MEDLINE
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En
Ano de publicação:
2020
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Article