Your browser doesn't support javascript.
loading
A new cyclopeptide alkaloid from Clematis Florida.
Wu, Ying; Zhang, Yi-Fan; Zhang, Hai-Tao; Ma, Xin-Hua; Yang, Na-Na; Feng, Shi-Biao; Zhong, Tian-Hua; Zhang, Yong-Hong.
Afiliação
  • Wu Y; Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China.
  • Zhang YF; Medical Imaging Department, First Affiliated Hospital of Fujian Medical University, Fuzhou, P.R. China.
  • Zhang HT; Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China.
  • Ma XH; Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China.
  • Yang NN; Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China.
  • Feng SB; Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China.
  • Zhong TH; Key Laboratory of Marine Biogenetic Resources, State Oceanic Administration, Third Institute of Oceanography, Xiamen, P.R. China.
  • Zhang YH; Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China.
Nat Prod Res ; 36(7): 1693-1699, 2022 Apr.
Article em En | MEDLINE | ID: mdl-32811200
ABSTRACT
One new 14-membered ring cyclopeptide alkaloid, plenane A (1), along with six known compounds (2-7), was isolated from the roots of Clematis florida. Their structures were elucidated by means of NMR spectroscopic analysis and mass spectrometry. In addition, their anti- inflammatory effects on lipopolysaccharide-induced RAW264.7 macrophages were evaluated in vitro. The compounds 1, 2 and 6 exhibited potent indirect inhibitory effects, with IC50 values of 40.92, 22.88 and 6.32 µM, respectively.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Clematis / Alcaloides Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Clematis / Alcaloides Idioma: En Ano de publicação: 2022 Tipo de documento: Article