Prolonged infusion of linezolid is associated with improved pharmacokinetic/pharmacodynamic (PK/PD) profiles in patients with external ventricular drains.

Zhao, Wenjun; Kong, Lingti; Wu, Chenchen; Wu, Xiaofei

Zhao, Wenjun; Kong, Lingti; Wu, Chenchen; Wu, Xiaofei.

Afiliação

Zhao W; Department of Critical Care Medicine, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, 230000, China.
Kong L; Department of Emergency Internal Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China.
Wu C; Departmen of Pharmacy, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China.
Wu X; Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China.

Eur J Clin Pharmacol ; 77(1): 79-86, 2021 Jan.

Article em En | MEDLINE | ID: mdl-32812063

Assuntos

Antibacterianos/administração & dosagem; Hemorragia Cerebral/cirurgia; Linezolida/administração & dosagem; Ventriculostomia; Idoso; Antibacterianos/sangue; Antibacterianos/líquido cefalorraquidiano; Antibacterianos/farmacocinética; Drenagem; Feminino; Humanos; Infusões Intravenosas; Linezolida/sangue; Linezolida/líquido cefalorraquidiano; Linezolida/farmacocinética; Masculino; Pessoa de Meia-Idade

Palavras-chave

Cerebrospinal fluid; External ventricular drains; Linezolid; Monte Carlo simulation; Pharmacodynamics; Pharmacokinetics; Prolonged infusion

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ventriculostomia / Hemorragia Cerebral / Linezolida / Antibacterianos Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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