A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation.

Schanin, Julia; Gebremeskel, Simon; Korver, Wouter; Falahati, Rustom; Butuci, Melina; Haw, Tatt Jhong; Nair, Prema M; Liu, Gang; Hansbro, Nicole G; Hansbro, Philip M; Evensen, Erik; Brock, Emily C; Xu, Alan; Wong, Alan; Leung, John; Bebbington, Christopher; Tomasevic, Nenad; Youngblood, Bradford A

Schanin, Julia; Gebremeskel, Simon; Korver, Wouter; Falahati, Rustom; Butuci, Melina; Haw, Tatt Jhong; Nair, Prema M; Liu, Gang; Hansbro, Nicole G; Hansbro, Philip M; Evensen, Erik; Brock, Emily C; Xu, Alan; Wong, Alan; Leung, John; Bebbington, Christopher; Tomasevic, Nenad; Youngblood, Bradford A.

Afiliação

Schanin J; Allakos, Inc Redwood City, CA, 94065, USA.
Gebremeskel S; Allakos, Inc Redwood City, CA, 94065, USA.
Korver W; Allakos, Inc Redwood City, CA, 94065, USA.
Falahati R; Allakos, Inc Redwood City, CA, 94065, USA.
Butuci M; Allakos, Inc Redwood City, CA, 94065, USA.
Haw TJ; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW 2305 and The University of Newcastle, Callaghan, NSW, 2208, Australia.
Nair PM; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW 2305 and The University of Newcastle, Callaghan, NSW, 2208, Australia.
Liu G; Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, and University of Technology Sydney, School of Life Sciences, Faculty of Science, Ultimo, NSW, 2007, Australia.
Hansbro NG; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW 2305 and The University of Newcastle, Callaghan, NSW, 2208, Australia.
Hansbro PM; Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, and University of Technology Sydney, School of Life Sciences, Faculty of Science, Ultimo, NSW, 2007, Australia.
Evensen E; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW 2305 and The University of Newcastle, Callaghan, NSW, 2208, Australia.
Brock EC; Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, and University of Technology Sydney, School of Life Sciences, Faculty of Science, Ultimo, NSW, 2007, Australia.
Xu A; Basis Bioscience, LLC, Foster City, CA, 94065, USA.
Wong A; Allakos, Inc Redwood City, CA, 94065, USA.
Leung J; Allakos, Inc Redwood City, CA, 94065, USA.
Bebbington C; Allakos, Inc Redwood City, CA, 94065, USA.
Tomasevic N; Allakos, Inc Redwood City, CA, 94065, USA.
Youngblood BA; Allakos, Inc Redwood City, CA, 94065, USA.

Mucosal Immunol ; 14(2): 366-376, 2021 03.

Article em En | MEDLINE | ID: mdl-32814824

Assuntos

Antígenos CD/metabolismo; Antígenos de Diferenciação de Linfócitos B/metabolismo; Lectinas/metabolismo; Mastócitos/imunologia; Pneumonia/imunologia; Doença Pulmonar Obstrutiva Crônica/metabolismo; Sistema Respiratório/imunologia; Animais; Anticorpos Monoclonais/metabolismo; Antígenos CD/genética; Antígenos de Diferenciação de Linfócitos B/genética; Degranulação Celular; Fumar Cigarros; Modelos Animais de Doenças; Perfilação da Expressão Gênica; Imunoglobulina E/metabolismo; Interleucina-33/metabolismo; Lectinas/genética; Camundongos; Camundongos Transgênicos; NF-kappa B/metabolismo; Ativação de Neutrófilo; Transdução de Sinais

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia / Sistema Respiratório / Antígenos de Diferenciação de Linfócitos B / Antígenos CD / Doença Pulmonar Obstrutiva Crônica / Lectinas / Mastócitos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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