DREIMT: a drug repositioning database and prioritization tool for immunomodulation.
Bioinformatics
; 37(4): 578-579, 2021 05 01.
Article
em En
| MEDLINE
| ID: mdl-32818254
ABSTRACT
MOTIVATION Drug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases. RESULTS:
DREIMT is a new hypothesis-generation web tool, which performs drug prioritization analysis for immunomodulation. DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4960 drug profiles and â¼2600 immune gene expression signatures. The tool also suggests potential immunomodulatory drugs targeting user-supplied gene expression signatures. Final output includes drug-signature association scores, FDRs and downloadable plots and results tables. AVAILABILITYAND IMPLEMENTATION http//www.dreimt.org. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
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MEDLINE
Assunto principal:
Reposicionamento de Medicamentos
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Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article