Prevention and treatment of SHIVAD8 infection in rhesus macaques by a potent d-peptide HIV entry inhibitor.
Proc Natl Acad Sci U S A
; 117(36): 22436-22442, 2020 09 08.
Article
em En
| MEDLINE
| ID: mdl-32820072
ABSTRACT
Cholesterol-PIE12-trimer (CPT31) is a potent d-peptide HIV entry inhibitor that targets the highly conserved gp41 N-peptide pocket region. CPT31 exhibited strong inhibitory breadth against diverse panels of primary virus isolates. In a simian-HIV chimeric virus AD8 (SHIVAD8) macaque model, CPT31 prevented infection from a single high-dose rectal challenge. In chronically infected animals, CPT31 monotherapy rapidly reduced viral load by â¼2 logs before rebound occurred due to the emergence of drug resistance. In chronically infected animals with viremia initially controlled by combination antiretroviral therapy (cART), CPT31 monotherapy prevented viral rebound after discontinuation of cART. These data establish CPT31 as a promising candidate for HIV prevention and treatment.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
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HIV
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Vírus da Imunodeficiência Símia
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Fármacos Anti-HIV
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Internalização do Vírus
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article