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Iridoid glycosides isolated from Nardostachys chinensis batal with NO production inhibitory activity.
Xue, Gui-Min; Zhao, Chen-Guang; Xue, Jin-Feng; Zhao, Zhen-Zhu; Si, Ying-Ying; Du, Kun; Sun, Yan-Jun; Feng, Wei-Sheng.
Afiliação
  • Xue GM; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
  • Zhao CG; Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou, China.
  • Xue JF; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
  • Zhao ZZ; Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou, China.
  • Si YY; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
  • Du K; Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou, China.
  • Sun YJ; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
  • Feng WS; Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou, China.
Nat Prod Res ; 36(7): 1700-1706, 2022 Apr.
Article em En | MEDLINE | ID: mdl-32820643
ABSTRACT
Investigation into the chemical diversity of Nardostachys chinensis Batal led to the discovery of three new (1-3) and one known (4) iridoid glycosides. Their structures were established through spectroscopic methods including 1 D and 2 D NMR experiments and HRESIMS analysis. Inhibitory effects of 1-4 on nitric oxide production were investigated in lipopolysaccaride (LPS)-mediated RAW 264.7 cells, and they displayed IC50 values in the range 7.8-15.2 µM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nardostachys Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nardostachys Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article