Tooth loss associated with the use of tenofovir disoproxil fumarate.
J Clin Pharm Ther
; 45(6): 1478-1482, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-32820829
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
The frequent tenofovir disoproxil fumarate (TDF)-related adverse drug reactions (ADRs) are nephrotoxicity and bone toxicity; however, tooth-related ADRs of TDF have not been reported. We describe the case of a 41-year-old Han Chinese man with chronic hepatitis B with TDF-associated tooth loss. CASESUMMARY:
He presented with halitosis, gingival swelling and tooth loss after TDF use. After excluding the possibility of other drug-related ADRs, TDF was considered a possible cause and switched with tenofovir alafenamide fumarate (TAF). After 6 months, the oral symptoms disappeared, with no additional tooth loss. WHAT IS NEW ANDCONCLUSION:
This is the first report of such ADRs. The ADR score was 7, indicating tooth loss as a potential TDF-related ADR.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Perda de Dente
/
Tenofovir
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article