In vivo imaging characterization of basal cell carcinoma and cutaneous response to high-dose ionizing radiation therapy: A prospective study of reflectance confocal microscopy, dermoscopy, and ultrasonography.
J Am Acad Dermatol
; 84(6): 1575-1584, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-32827607
ABSTRACT
BACKGROUND:
Radiation therapy (RT) is a treatment option for select skin cancers. The histologic effects of RT on normal skin or skin cancers are not well characterized. Dermoscopy, high-frequency ultrasonography (HFUS), and reflectance confocal microscopy (RCM) are noninvasive imaging modalities that may help characterize RT response.OBJECTIVES:
To describe changes in the tumor and surrounding skin of patients with basal cell carcinoma (BCC) treated with RT.METHODS:
The study was conducted between 2014 and 2018. Patients with biopsy-proven BCCs were treated with 42 Gy in 6 fractions using a commercially available brachytherapy device. Dermoscopy, HFUS, and RCM were performed before treatment and at 6 weeks, 3 months, and 12 months after RT.RESULTS:
A total of 137 imaging assessments (RCM + dermoscopy + HFUS) were performed in 12 patients. BCC-specific features were present in 81.8%, 91%, and 17% of patients imaged with dermoscopy, RCM, and HFUS at baseline, respectively, before treatment. After treatment, the resolution of these features was noted in 33.4%, 91.7%, and 100% of patients imaged with the respective modalities. No recurrences were seen after a mean of 31.7 months of follow-up.LIMITATIONS:
Small sample size and no histopathologic correlation.CONCLUSION:
Dermoscopy and HFUS were not as reliable as RCM at characterizing BCC RT response.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Pele
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Neoplasias Cutâneas
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Carcinoma Basocelular
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Fracionamento da Dose de Radiação
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Recidiva Local de Neoplasia
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Observational_studies
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Prognostic_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article