GBAT: a gene-based association test for robust detection of trans-gene regulation.
Genome Biol
; 21(1): 211, 2020 08 24.
Article
em En
| MEDLINE
| ID: mdl-32831138
ABSTRACT
The observation that disease-associated genetic variants typically reside outside of exons has inspired widespread investigation into the genetic basis of transcriptional regulation. While associations between the mRNA abundance of a gene and its proximal SNPs (cis-eQTLs) are now readily identified, identification of high-quality distal associations (trans-eQTLs) has been limited by a heavy multiple testing burden and the proneness to false-positive signals. To address these issues, we develop GBAT, a powerful gene-based pipeline that allows robust detection of high-quality trans-gene regulation signal.
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Base de dados:
MEDLINE
Assunto principal:
Regulação da Expressão Gênica
/
Testes Genéticos
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Estudo de Associação Genômica Ampla
Tipo de estudo:
Diagnostic_studies
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Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article