Longitudinal changes in insulin resistance in children with epilepsy on ketogenic diet: Prevalence and risk factors.
Epilepsy Behav
; 112: 107393, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32839143
ABSTRACT
INTRODUCTION:
The aim of the study was to evaluate the incidence of insulin resistance (IR) and the associated risk factors in children with epilepsy on a ketogenic diet (KD).METHODS:
This longitudinal cohort study analyzed data of children with epilepsy on KD. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). The HOMA-IR value, fasting serum insulin levels, fasting glucose (FG) levels, and lipid profiles were measured before the initiation of the KD and at 6- to 12-month intervals.RESULTS:
A total of 28 children were enrolled. The median age at the initiation of KD was 2.7⯱â¯2.4â¯years, and the median follow-up duration was 2.1⯱â¯1.4â¯years. The median HOMA-IR (HOMA-IR-1) value before the initiation of KD was 1.2⯱â¯0.2, which significantly increased to 1.8⯱â¯0.3 at the last follow-up (HOMA-IR-2; ∆HOMA-IRâ¯=â¯0.6⯱â¯0.3, pâ¯<â¯0.001). The following factors were associated with patients with higher HOMA-IR-2 values (≥1.9) younger age at seizure onset (0.3⯱â¯0.2â¯years, pâ¯<â¯0.001), at the initiation of antiepileptic drugs (AEDs; 0.3⯱â¯0.3â¯years, pâ¯<â¯0.001), and at the initiation of KD (1.3⯱â¯0.5â¯years, pâ¯<â¯0.001) and higher serum alanine transaminase (ALT; 84.0⯱â¯17.8â¯U/L, pâ¯=â¯0.022), total cholesterol (TC; 245.0⯱â¯20.1â¯mg/dL, pâ¯=â¯0.001), low-density lipoprotein cholesterol (LDL-C, 103.0⯱â¯6.7â¯mg/dL, pâ¯=â¯0.003), and triglyceride (387.0⯱â¯28.8â¯mg/dL, pâ¯<â¯0.001) levels. Multivariate regression analysis revealed that the age at seizure onset (pâ¯=â¯0.002), at initiation of AEDs (pâ¯=â¯0.021), and at initiation of KD (pâ¯=â¯0.022) and serum levels of LDL-C (pâ¯=â¯0.012) and triglycerides (pâ¯=â¯0.026) were associated with a significantly high HOMA-IR-2 value.CONCLUSION:
Close monitoring of serum lipids levels, especially at younger age, may aid in detecting exacerbation of IR.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Epilepsia
/
Dieta Cetogênica
Tipo de estudo:
Etiology_studies
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Observational_studies
/
Prevalence_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article