Neuromuscular Complications of Statin Therapy.
Curr Neurol Neurosci Rep
; 20(10): 47, 2020 08 25.
Article
em En
| MEDLINE
| ID: mdl-32839913
ABSTRACT
PURPOSE OF REVIEW This review provides an overview of neuromuscular side effects associated with statin use, their diagnosis, and treatment. RECENT FINDINGS:
The discovery of anti-HMGCR antibodies led to a better understanding of clinical aspects of statin-associated anti-HMGCR myopathy and its treatment. Statins are widely prescribed medications with well-established benefits in the treatment of cardiovascular diseases and stroke. Adherence to statins is influenced by development of side effects, especially muscle related. There is wide range of neuromuscular side effects associated with statin therapy. Documented neuromuscular side effects include asymptomatic elevation of muscle enzymes, mild-moderate myalgias and cramps, toxic and immune-mediated severe necrotizing myopathy, and rare cases of rhabdomyolysis. In addition, statins can lead to unmasking or triggering of underlying muscle and neuromuscular junction disorders. This article identifies the risk factors and provides a review of neuromuscular side effects associated with statin use, their diagnosis and treatment.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Doenças Musculares
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article