Cyclosporin A but not FK506 activates the integrated stress response in human cells.

Fedele, Anthony O; Carraro, Valérie; Xie, Jianling; Averous, Julien; Proud, Christopher G

Fedele, Anthony O; Carraro, Valérie; Xie, Jianling; Averous, Julien; Proud, Christopher G.

Afiliação

Fedele AO; Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health & Medical Research Institute, North Terrace Campus, Adelaide, Australia.
Carraro V; INRAE Unité de Nutrition Humaine, Université Clermont Auvergne, Clermont-Ferrand, France.
Xie J; Lifelong Health Theme, South Australian Health & Medical Research Institute, North Terrace Campus, Adelaide, Australia.
Averous J; INRAE Unité de Nutrition Humaine, Université Clermont Auvergne, Clermont-Ferrand, France.
Proud CG; Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health & Medical Research Institute, North Terrace Campus, Adelaide, Australia; Lifelong Health Theme, South Australian Health & Medical Research Institute, North Terrace Campus, Adelaide, Australia; School of Biologica

J Biol Chem ; 295(44): 15134-15143, 2020 10 30.

Article em En | MEDLINE | ID: mdl-32843478

Assuntos

Ciclosporina/farmacologia; Imunossupressores/farmacologia; Estresse Fisiológico/efeitos dos fármacos; Tacrolimo/farmacologia; Células A549; Fator 4 Ativador da Transcrição/metabolismo; Animais; Células Cultivadas; Células HeLa; Humanos; Camundongos; Fosforilação

Palavras-chave

FK506; cyclosporin; immunosuppressor; protein kinase; protein synthesis; stress response; translation initiation factor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estresse Fisiológico / Tacrolimo / Ciclosporina / Imunossupressores Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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