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Photocontrol of Endogenous Glycine Receptors In Vivo.
Gomila, Alexandre M J; Rustler, Karin; Maleeva, Galyna; Nin-Hill, Alba; Wutz, Daniel; Bautista-Barrufet, Antoni; Rovira, Xavier; Bosch, Miquel; Mukhametova, Elvira; Petukhova, Elena; Ponomareva, Daria; Mukhamedyarov, Marat; Peiretti, Franck; Alfonso-Prieto, Mercedes; Rovira, Carme; König, Burkhard; Bregestovski, Piotr; Gorostiza, Pau.
Afiliação
  • Gomila AMJ; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain.
  • Rustler K; University of Regensburg, Institute of Organic Chemistry, Regensburg 93053, Germany.
  • Maleeva G; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain; Aix-Marseille Université, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille 13005, France.
  • Nin-Hill A; University of Barcelona, Department of Inorganic and Organic Chemistry, Institute of Theoretical Chemistry (IQTCUB), Barcelona 08028, Spain.
  • Wutz D; University of Regensburg, Institute of Organic Chemistry, Regensburg 93053, Germany.
  • Bautista-Barrufet A; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain.
  • Rovira X; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain.
  • Bosch M; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain.
  • Mukhametova E; Aix-Marseille Université, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille 13005, France; Kazan Federal University, Open Lab of Motor Neurorehabilitation, Kazan, Russia.
  • Petukhova E; Institute of Neurosciences, Kazan State Medical University, Kazan, Russia.
  • Ponomareva D; Institute of Neurosciences, Kazan State Medical University, Kazan, Russia.
  • Mukhamedyarov M; Institute of Neurosciences, Kazan State Medical University, Kazan, Russia.
  • Peiretti F; Aix Marseille Université, INSERM 1263, INRA 1260, C2VN, Marseille, France.
  • Alfonso-Prieto M; Institute for Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Computational Biomedicine, Forschungszentrum Jülich, 52425 Jülich, Germany; Cécile and Oskar Vogt Institute for Brain Research, Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
  • Rovira C; University of Barcelona, Department of Inorganic and Organic Chemistry, Institute of Theoretical Chemistry (IQTCUB), Barcelona 08028, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08003 Spain. Electronic address: c.rovira@ub.edu.
  • König B; University of Regensburg, Institute of Organic Chemistry, Regensburg 93053, Germany. Electronic address: burkhard.koenig@chemie.uni-regensburg.de.
  • Bregestovski P; Aix-Marseille Université, INSERM, INS, Institut de Neurosciences des Systèmes, Marseille 13005, France; Institute of Neurosciences, Kazan State Medical University, Kazan, Russia. Electronic address: pbreges@gmail.com.
  • Gorostiza P; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08003 Spain; CIBER-BBN, Madrid 28001 Spain. Electronic address: pau@icrea.cat.
Cell Chem Biol ; 27(11): 1425-1433.e7, 2020 11 19.
Article em En | MEDLINE | ID: mdl-32846115
ABSTRACT
Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Azo / Receptores de Glicina Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Azo / Receptores de Glicina Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article