Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2.

Alam, Intikhab; Kamau, Allan A; Kulmanov, Maxat; Jaremko, Lukasz; Arold, Stefan T; Pain, Arnab; Gojobori, Takashi; Duarte, Carlos M

Alam, Intikhab; Kamau, Allan A; Kulmanov, Maxat; Jaremko, Lukasz; Arold, Stefan T; Pain, Arnab; Gojobori, Takashi; Duarte, Carlos M.

Afiliação

Alam I; Biological and Environmental Science and Engineering (BESE), Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Kamau AA; Biological and Environmental Science and Engineering (BESE), Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Kulmanov M; Biological and Environmental Science and Engineering (BESE), Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Jaremko L; Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Arold ST; Biological and Environmental Science and Engineering (BESE), Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Pain A; Centre de Biochimie Structurale, CNRS, INSERM, Université de Montpellier, Montpellier, France.
Gojobori T; Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Duarte CM; Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.

Front Cell Infect Microbiol ; 10: 405, 2020.

Article em En | MEDLINE | ID: mdl-32850499

Assuntos

Betacoronavirus/química; Proteínas do Envelope Viral/química; Proteínas do Envelope Viral/genética; COVID-19; Proteínas do Envelope de Coronavírus; Infecções por Coronavirus/virologia; Genes Essenciais; Genes Virais; Genoma Viral; Humanos; Coronavírus da Síndrome Respiratória do Oriente Médio/química; Coronavírus da Síndrome Respiratória do Oriente Médio/genética; Mutação; Fases de Leitura Aberta; Domínios PDZ; Pandemias; Pneumonia Viral/virologia; Domínios Proteicos; Coronavírus Relacionado à Síndrome Respiratória Aguda Grave/química; SARS-CoV-2; Proteínas Viroporinas

Palavras-chave

ARDS (acute respiratory distress syndrome); COVID-19; E protein Inhibitors; SARS-CoV-2; envelope protein (E); therapeutic targets

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas do Envelope Viral / Betacoronavirus Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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