Identification of creatine kinase and alpha-1 antitrypsin as protein targets of alkylation by sulfur mustard.

Lüling, Robin; Schmeißer, Wolfgang; Siegert, Markus; Mückter, Harald; Dietrich, Alexander; Thiermann, Horst; Gudermann, Thomas; John, Harald; Steinritz, Dirk

Lüling, Robin; Schmeißer, Wolfgang; Siegert, Markus; Mückter, Harald; Dietrich, Alexander; Thiermann, Horst; Gudermann, Thomas; John, Harald; Steinritz, Dirk.

Afiliação

Lüling R; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Schmeißer W; Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität Munich, Munich, Germany.
Siegert M; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Mückter H; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Dietrich A; Department of Chemistry, Humboldt-Universität zu Berlin, Berlin, Germany.
Thiermann H; Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität Munich, Munich, Germany.
Gudermann T; Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität Munich, Munich, Germany.
John H; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Steinritz D; Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität Munich, Munich, Germany.

Drug Test Anal ; 13(2): 268-282, 2021 Feb.

Article em En | MEDLINE | ID: mdl-32852113

Assuntos

Alquilação/efeitos dos fármacos; Substâncias para a Guerra Química/efeitos adversos; Creatina Quinase/metabolismo; Gás de Mostarda/efeitos adversos; alfa 1-Antitripsina/metabolismo; Creatina Quinase/química; Células HEK293; Humanos; Modelos Moleculares; alfa 1-Antitripsina/química

Palavras-chave

2D-thiol-DIGE; CEES; alkylating agents; high-resolution mass spectrometry; thiol groups

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Substâncias para a Guerra Química / Alfa 1-Antitripsina / Creatina Quinase / Alquilação / Gás de Mostarda Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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