Tumor Necrosis Factor &#945; Influences Phenotypic Plasticity and Promotes Epigenetic Changes in Human Basal Forebrain Cholinergic Neuroblasts.

Guarnieri, Giulia; Sarchielli, Erica; Comeglio, Paolo; Herrera-Puerta, Erika; Piaceri, Irene; Nacmias, Benedetta; Benelli, Matteo; Kelsey, Gavin; Maggi, Mario; Gallina, Pasquale; Vannelli, Gabriella Barbara; Morelli, Annamaria

Tumor Necrosis Factor α Influences Phenotypic Plasticity and Promotes Epigenetic Changes in Human Basal Forebrain Cholinergic Neuroblasts.

Guarnieri, Giulia; Sarchielli, Erica; Comeglio, Paolo; Herrera-Puerta, Erika; Piaceri, Irene; Nacmias, Benedetta; Benelli, Matteo; Kelsey, Gavin; Maggi, Mario; Gallina, Pasquale; Vannelli, Gabriella Barbara; Morelli, Annamaria.

Afiliação

Guarnieri G; Section of Human Anatomy and Histology, Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Sarchielli E; Section of Human Anatomy and Histology, Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Comeglio P; Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.
Herrera-Puerta E; Biology Group CES-EIA, CES University, Medellín 050021, Colombia.
Piaceri I; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50134 Florence, Italy.
Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50134 Florence, Italy.
Benelli M; Bioinformatics Unit, Hospital of Prato, Azienda USL Toscana Centro, 50122 Prato, Italy.
Kelsey G; Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK.
Maggi M; Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 1TN, UK.
Gallina P; Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.
Vannelli GB; Neurosurgical Unit, Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, 50134 Florence, Italy.
Morelli A; Section of Human Anatomy and Histology, Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.

Int J Mol Sci ; 21(17)2020 Aug 25.

Article em En | MEDLINE | ID: mdl-32854421

Assuntos

Prosencéfalo Basal/citologia; Núcleo Basal de Meynert/citologia; Metilação de DNA; Fator de Necrose Tumoral alfa/metabolismo; Prosencéfalo Basal/efeitos dos fármacos; Prosencéfalo Basal/metabolismo; Núcleo Basal de Meynert/efeitos dos fármacos; Núcleo Basal de Meynert/metabolismo; Linhagem Celular; Neurônios Colinérgicos/citologia; Neurônios Colinérgicos/metabolismo; Metilação de DNA/efeitos dos fármacos; Epigênese Genética/efeitos dos fármacos; Humanos; Proteínas Associadas aos Microtúbulos/genética; Proteínas do Tecido Nervoso/genética; Plasticidade Neuronal/efeitos dos fármacos; Receptores de Fator de Crescimento Neural/genética; Receptores Tipo II do Fator de Necrose Tumoral/genética; Fator de Necrose Tumoral alfa/farmacologia; Sequenciamento Completo do Genoma

Palavras-chave

Alzheimer's disease; DNA methylation; NGF; TNFα receptors; ciliogenesis; human fetal neurons; neurogenesis; neuroinflammation; nucleus basalis of Meynert

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Metilação de DNA / Núcleo Basal de Meynert / Prosencéfalo Basal Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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