Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy.
Mol Cancer
; 19(1): 133, 2020 08 27.
Article
em En
| MEDLINE
| ID: mdl-32854711
ABSTRACT
Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its downstream effector, stimulator of interferon genes (STING), are involved in mediating fundamental innate antimicrobial immunity by promoting the release of type I interferons (IFNs) and other inflammatory cytokines. Accumulating evidence suggests that the activation of the cGAS-STING axis is critical for antitumor immunity. The downstream cytokines regulated by cGAS-STING, especially type I IFNs, serve as bridges connecting innate immunity with adaptive immunity. Accordingly, a growing number of studies have focused on the synthesis and screening of STING pathway agonists. However, chronic STING activation may lead to a protumor phenotype in certain malignancies. Hence, the cGAS-STING signaling pathway must be orchestrated properly when STING agonists are used alone or in combination. In this review, we discuss the dichotomous roles of the cGAS-STING pathway in tumor development and the latest advances in the use of STING agonists.
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Base de dados:
MEDLINE
Assunto principal:
Carcinogênese
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Proteínas de Membrana
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Neoplasias
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Nucleotidiltransferases
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article