Zika virus infection enhances future risk of severe dengue disease.
Science
; 369(6507): 1123-1128, 2020 08 28.
Article
em En
| MEDLINE
| ID: mdl-32855339
The Zika pandemic sparked intense interest in whether immune interactions among dengue virus serotypes 1 to 4 (DENV1 to -4) extend to the closely related Zika virus (ZIKV). We investigated prospective pediatric cohorts in Nicaragua that experienced sequential DENV1 to -3 (2004 to 2015), Zika (2016 to 2017), and DENV2 (2018 to 2020) epidemics. Risk of symptomatic DENV2 infection and severe disease was elevated by one prior ZIKV infection, one prior DENV infection, or one prior DENV infection followed by one ZIKV infection, compared with being flavivirus-naïve. By contrast, multiple prior DENV infections reduced dengue risk. Further, although high preexisting anti-DENV antibody titers protected against DENV1, DENV3, and ZIKV disease, intermediate titers induced by previous ZIKV or DENV infection enhanced future risk of DENV2 disease and severity, as well as DENV3 severity. The observation that prior ZIKV infection can modulate dengue disease severity like a DENV serotype poses challenges to development of dengue and Zika vaccines.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dengue Grave
/
Vírus da Dengue
/
Zika virus
/
Infecção por Zika virus
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
País como assunto:
America central
/
Nicaragua
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article