TIM-3 Expression Is Downregulated on Human NK Cells in Response to Cancer Targets in Synergy with Activation.
Cancers (Basel)
; 12(9)2020 Aug 26.
Article
em En
| MEDLINE
| ID: mdl-32858904
ABSTRACT
Among natural killer (NK) cell receptors, the T-cell immunoglobulin and mucin-containing domain (TIM-3) has been associated with both inhibitory and activating functions, depending on context and activation pathway. Ex vivo and in vitro, expression of TIM-3 is inducible and depends on activation stimulus. Here, we report that TIM-3 expression can be downregulated on NK cells under specific conditions. When NK cells are exposed to cancer targets, they synergize with stimulation conditions to induce a substantial decrease in TIM-3 expression on their surface. We found that such downregulation occurs following prior NK activation. Downregulated TIM-3 expression correlated to lower cytotoxicity and lower interferon gamma (IFN-γ) expression, fueling the notion that TIM-3 might function as a benchmark for human NK cell dysfunction.
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MEDLINE
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En
Ano de publicação:
2020
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Article